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Pulse oximetry is a test used to measure the oxygen level (oxygen saturation) of the blood. It is an easy, painless measure of how well oxygen is being sent to parts of your body furthest from your heart, such as the arms and legs. Blood Volume Deficiency. Conditions, such as hypovolemia, hypotension, and hypothermia, may have adequate oxygen saturation, but low oxygen carrying capacity. Due to the reduction in blood flow, the sensor may not be able to pick up adequately the pulsatile waveform resulting in no signal or loss of accuracy.